Ca2+ sensor-mediated ROS scavenging suppresses rice immunity and is exploited by a fungal effector

文献类型： 外文期刊

第一作者： Gao, Mingjun

作者： Gao, Mingjun;He, Yang;Yin, Xin;Zhong, Xiangbin;Yan, Bingxiao;Wu, Yue;Chen, Jin;Zhai, Keran;Huang, Yifeng;Gong, Xiangyu;Chang, Huizhong;Liu, Jiyun;Deng, Yiwen;Wang, Ertao;Yang, Weibing;He, Zuhua;Li, Xiaoyuan;Xie, Shenghan;Yue, Jiaxing;Xu, Jianlong;Zhang, Guiquan;Tharreau, Didier;Wang, Guo-Liang;Yang, Weibing;Yin, Xin;Zhong, Xiangbin;Zhong, Xiangbin

作者机构：

期刊名称：CELL （ 影响因子：41.584； 五年影响因子：46.899 ）

ISSN： 0092-8674

年卷期： 2021 年 184 卷 21 期

页码：

收录情况： SCI

摘要： Plant immunity is activated upon pathogen perception and often affects growth and yield when it is constitutively active. How plants fine-tune immune homeostasis in their natural habitats remains elusive. Here, we discover a conserved immune suppression network in cereals that orchestrates immune homeostasis, centering on a Ca2+-sensor, RESISTANCE OF RICE TO DISEASES1 (ROD1). ROD1 promotes reactive oxygen species (ROS) scavenging by stimulating catalase activity, and its protein stability is regulated by ubiquitination. ROD1 disruption confers resistance to multiple pathogens, whereas a natural ROD1 allele prevalent in indica rice with agroecology-specific distribution enhances resistance without yield penalty. The fungal effector AvrPiz-t structurally mimics ROD1 and activates the same ROS-scavenging cascade to suppress host immunity and promote virulence. We thus reveal a molecular framework adopted by both host and pathogen that integrates Ca2+ sensing and ROS homeostasis to suppress plant immunity, suggesting a principle for breeding disease-resistant, high-yield crops.

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