Citrus aurantium 'Changshan-huyou' physiological premature fruit drop: A promising prebiotic to tackle obesity

文献类型： 外文期刊

第一作者： Wang, Chao

作者： Wang, Chao;Peng, Mingfang;Fu, Fuhua;Li, Gaoyang;Su, Donglin;Huang, Lvhong;Guo, Jiajing;Shan, Yang;Wang, Chao;Peng, Mingfang;Fu, Fuhua;Li, Gaoyang;Su, Donglin;Huang, Lvhong;Guo, Jiajing;Shan, Yang;Wang, Chao;Peng, Mingfang;Fu, Fuhua;Li, Gaoyang;Su, Donglin;Huang, Lvhong;Guo, Jiajing;Shan, Yang;Gao, Zhipeng

作者机构：

关键词： Citrus aurantium 'Changshan-huyou'; Functional food; Transcriptome; Microbiome; Fecal microbiota transplantation; AMPK

期刊名称：PHYTOMEDICINE （ 影响因子：8.3； 五年影响因子：8.0 ）

ISSN： 0944-7113

年卷期： 2025 年 136 卷

页码：

收录情况： SCI

摘要： Background: Presently, the mitigation and governance of obesity have surfaced as significant public health dilemmas on a global scale. A wealth of studies indicated that the host gut microbiota is instrumental in regulating the interplay between high-fat diet (HFD) intake and the pathogenesis of obesity. Physiological premature fruit drop, a major byproduct of citrus, is rich in a variety of bioactive constituents, yet its potential has remained underutilized for an extended period. Purpose: The objective of this investigation is to examine the chemical constituents of Citrus aurantium'Chang- shan-huyou' premature fruit drop (HYFD) and investigate its anti-obesity effects, elucidating its potential pathways. Methods: Volatile compounds and flavonoids in HYFD were analyzed using chromatographic and mass spectrometric techniques. Furthermore, this study utilized biochemical assays and histopathological examinations to evaluate the effects of HYFD on HFD-fed mice. The impact of HYFD on the gut microbiota of the mice was examined through 16S rRNA gene sequencing, and fecal microbiota transplantation was employed to validate the role of the gut microbial community in host obesity prevention. Concurrently, transcriptome was employed to identify differentially expressed genes, providing further insights into the molecular mechanisms through which HYFD manifests its anti-obesity effects. Results: Our findings demonstrated that HYFD supplementation significantly alleviated adiposity and ameliorated the dysbiosis of gut microbiota in HFD-induced mice. HYFD rectified the HFD-induced gut microbiota dysregulation, enhanced the presence of beneficial microbial taxa linked to lipid metabolism, including Parabacteroides and Alistipes, and elevated concentrations of the anti-obesity short-chain fatty acids, comprising caproic acid and isocaproic acid. Additionally, transcriptomic analyses confirmed that HYFD prevented obesity in mice by enhancing fatty acid catabolism via the activation of the AMPK/PPAR alpha/CPT1a signaling pathway. Conclusion: Our results provided novel insights into the mechanism of citrus physiological premature fruit drop and its potential role in preventing obesity, while sparking greater interest in leveraging more biomass waste.

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