Circadian orchestration of host and gut microbiota in infection

文献类型： 外文期刊

第一作者： Xia, Yaoyao

作者： Xia, Yaoyao;Ding, Xuezhi;Wang, Shengyi;Xia, Yaoyao;Ren, Wenkai

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关键词： circadian rhythmicity; intestinal microbiota; pathogen infection; sepsis; COVID-19

期刊名称：BIOLOGICAL REVIEWS （ 影响因子：14.35； 五年影响因子：14.786 ）

ISSN： 1464-7931

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收录情况： SCI

摘要： Circadian rhythms are present in almost every organism and regulate multiple aspects of biological and physiological processes (e.g. metabolism, immune responses, and microbial exposure). There exists a bidirectional circadian interaction between the host and its gut microbiota, and potential circadian orchestration of both host and gut microbiota in response to invading pathogens. In this review, we summarize what is known about these intestinal microbial oscillations and the relationships between host circadian clocks and various infectious agents (bacteria, fungi, parasites, and viruses), and discuss how host circadian clocks prime the immune system to fight pathogen infections as well as the direct effects of circadian clocks on viral activity (e.g. SARS-CoV-2 entry and replication). Finally, we consider strategies employed to realign normal circadian rhythmicity for host health, such as chronotherapy, dietary intervention, good sleep hygiene, and gut microbiota-targeted therapy. We propose that targeting circadian rhythmicity may provide therapeutic opportunities for the treatment of infectious diseases.

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