Transcriptome analysis revealed that delaying first colostrum feeding postponed ileum immune system development of neonatal calves

文献类型： 外文期刊

第一作者： Song, Yang

作者： Song, Yang;Song, Yang;Sun, Huizeng;He, Zhixiong;Guan, Le Luo;Song, Yang;Sun, Huizeng;He, Zhixiong;Fischer-Tlustos, Amanda;Steele, Michael;Ma, Tao

作者机构：

关键词： Neonatal calf; Delayed colostrum feeding; Ileal transcriptome; Immune functions; Host-microbial interactions

期刊名称：GENOMICS （ 影响因子：5.736； 五年影响因子：4.939 ）

ISSN： 0888-7543

年卷期： 2021 年 113 卷 6 期

页码：

收录情况： SCI

摘要： Our objective was to evaluate the effect of colostrum feeding times on genome-wide gene expression of neonatal calves. In total, twenty-seven calves were assigned to three colostrum feeding treatments: within 45 min (TRT0h, n = 9), 6 h (TRT6h, n = 9) and 12 h (TRT12h, n = 9). Ileum tissues were collected at 51 h and transcriptomic analysis was conducted. Uniquely expressed genes were identified in TRT0h group with enriched "Antigen Presentation" function. Meanwhile, the weighted gene co-expression network analysis (WGCNA) identified four significant gene modules (|correlation| 0.50 and P <= 0.05). In particular, Turquoise gene module with the enriched "Cadherin binding involved in cell-cell adhesion" and "Cell-cell adherences junction" GO terms were significantly correlated with Faecalibacterium prausnitzii (R = -0.70, P < 0.01) and Bifidobacterium (R = -0.55, P < 0.01). Our findings suggest feeding colostrum without delay could stimulate the expression of genes involved in immune function development related to host response and microbial colonization in neonatal claves.

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