Discovery of a novel genogroup feline calicivirus through molecular evolution in group-housed cats in China

文献类型： 外文期刊

第一作者： Zhang, Ya

作者： Zhang, Ya;Qian, Jing;Xia, Xingxia;Xu, Siyu;Li, Zhimin;Zhu, Yumei;Tan, Yeping;Bi, Zhenwei;Cheng, Zheng;Cheng, Zheng;Guo, Cunjie;Yang, Tong;Zhang, Haitao;Zhang, Ya;Qian, Jing;Xia, Xingxia;Xu, Siyu;Li, Zhimin;Zhu, Yumei;Tan, Yeping;Bi, Zhenwei;Cheng, Zheng;Zhao, Wen;Bi, Junming;Zhou, Dawei

作者机构：

期刊名称：SCIENTIFIC REPORTS （ 影响因子：3.9； 五年影响因子：4.3 ）

ISSN： 2045-2322

年卷期： 2025 年 15 卷 1 期

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收录情况： SCI

摘要： Feline calicivirus (FCV) is a highly infectious pathogen that causes upper respiratory tract disease (URTD), with a higher prevalence in group-housed cats compared to those raised individually. In this study, 15 FCV strains were isolated from group-housed cats exhibiting URTD symptoms in Changzhou, China, in 2024. Phylogenetic analysis based on the VP1 sequences revealed that 13 of 15 strains clustered within genogroup I (G I), while none belonged to genogroup II (G II). Notably, the remaining two strains grouped with several recently published Chinese isolates, forming an independent branch distinct from both G I and G II, proposed as genogroup III (G III). The VP1 proteins of the 13 G I strains exhibited specific residues 377N, 539A, and 557G, consistent with the established G I-specific markers (377N/S, 539A/P, and 557G). In contrast, G II strains typically retain 377 K, 539 V, and 557S. Interestingly, the G III strains displayed 377N, 539A (specific to G I) and 557S (specific to G II). Recombinant analysis found that co-circulating G I and G III resulted in a recombinant strain. Furthermore, neutralization tests demonstrated poor cross-neutralization between G I and G III strains. This study provides valuable insights for the development of effective vaccination strategies.

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