Preparation of a novel brain-targeted EGCG liposome and its antioxidative neuroprotection

文献类型： 外文期刊

第一作者： Xia, Chen

作者： Xia, Chen;Zhu, Yongqing;Deng, Junlin;Xiang, Zuoya;Yu, Manyou;Guo, Yi;Chen, Jian;Wang, Siqi;Yang, Chunyan;Wu, Yong;Liu, Gang;Zhao, Jiayuan;Guo, Yi

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关键词： EGCG; Glucose-modified liposomes; Brain targeting; Antioxidant; Neuroprotection

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.6； 五年影响因子：5.3 ）

ISSN： 1756-4646

年卷期： 2023 年 111 卷

页码：

收录情况： SCI

摘要： (-)-Epigallocatechin-3-gallate (EGCG) possesses potent antioxidant and neuroprotective properties. In this study, a novel glucose-modified EGCG encapsulated liposome (EGCG-Glu-Lip) was developed and characterized. EGCGGlu-Lip liposome's cytotoxicity, brain targeting ability, and its antioxidative neuroprotection were examined via bEnd.3 and PC12 cells testing. EGCG-Glu-Lip liposome particle mean size was 158.7 nm, with encapsulation efficiency 73.05 % under EGCG/lipid mass ratio 1:22 and soybean phospholipids (SPC) to cholesterol (Chol) mass ratio 3.84:1. EGCG-Glu-Lip exhibited less cytotoxicity, stronger protection to PC12 cells from H2O2 induced oxidative damage, keeping reactive oxygen species (ROS) level. Glucose modified liposome (Glu-Lip) cellular uptake in bEnd.3 and PC12 cells were 1.5-fold and 1.3-fold higher than that of Lip, supporting EGCG-Glu-Lip possessing enhanced blood-brain barrier (BBB) permeability mediated via glucose transporter protein 1 (GLUT1) and neuronal cell uptake for brain targeting. EGCG-Glu-Lip could provide an efficient nano delivery pathway to deliver sufficient EGCG to brain tissue exerting its antioxidative neuroprotection more efficiently.

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