Construction of quaternary ammonium chitosan-coated protein nanoparticles as novel delivery system for curcumin: Characterization, stability, antioxidant activity and bio-accessibility

文献类型： 外文期刊

第一作者： Liu, Qianyuan

作者： Liu, Qianyuan;Zhang, Qian;Jia, Feihong;Jiang, Ning;Wang, Cheng;Sun, Rongxue;Ma, Yanhong;Liu, Qianyuan;Zhang, Qian;Jia, Feihong;Jiang, Ning;Wang, Cheng;Sun, Rongxue;Ma, Yanhong;Zhang, Qian

作者机构：

关键词： Curcumin; Zein; Sodium caseinate; Quaternary ammonium chitosan; Protein -polysaccharide nanoparticles; Delivery system

期刊名称：FOOD CHEMISTRY （ 影响因子：8.5； 五年影响因子：8.2 ）

ISSN： 0308-8146

年卷期： 2024 年 455 卷

页码：

收录情况： SCI

摘要： This research aimed to develop a novel, effective, and stable delivery system based on zein (ZE), sodium caseinate (SC), and quaternary ammonium chitosan (HACC) for curcumin (CUR). The pH-driven self-assembly combined with electrostatic deposition methods were employed to construct CUR-loaded ZE-SC nanoparticles with HACC coating (ZE-SC@HACC). The optimized nanocomposite was prepared at ZE:SC:HACC:CUR mass ratios of 1:1:2:0.1, and it had encapsulation efficiency of 89.3%, average diameter of 218.2 nm, and zeta-potential of 40.7 mV. The assembly of composites and encapsulation of CUR were facilitated primarily by hydrophobic, hydrogen-bonding, and electrostatic interactions. Physicochemical stability analysis revealed that HACC coating dramatically enhanced ZE-SC nanoparticles' colloidal stability and CUR's resistance to chemical degradation. Additionally, antioxidant activity and simulated digestion results indicated that CUR-ZE-SC@HACC nanoparticles showed higher free radical scavenging capacity and bio-accessibility of CUR than CUR-ZE-SC nanoparticles and free CUR. Therefore, the ZE-SC@HACC nanocomposite is an effective and viable delivery system for CUR.

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