Genome-wide association studies for loin muscle area, loin muscle depth and backfat thickness in DLY pigs

文献类型： 外文期刊

第一作者： Zhao, Xiang

作者： Zhao, Xiang;Qiu, Yibin;Zhuang, Zhanwei;Ruan, Donglin;Wu, Jie;Ma, Fucai;Zheng, Enqin;Cai, Gengyuan;Yang, Jie;Wu, Zhenfang;Zhao, Xiang;Qiu, Yibin;Zhuang, Zhanwei;Ruan, Donglin;Wu, Jie;Ma, Fucai;Zheng, Enqin;Cai, Gengyuan;Yang, Jie;Wu, Zhenfang;Meng, Fanming;Zheng, Enqin;Cai, Gengyuan;Yang, Jie;Wu, Zhenfang;Cai, Gengyuan;Yang, Ming;Yang, Ming;Wu, Zhenfang

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关键词： backfat thickness; genome-wide association study; loin muscle area; loin muscle depth; SNP

期刊名称：ANIMAL GENETICS （ 影响因子：2.4； 五年影响因子：2.8 ）

ISSN： 0268-9146

年卷期： 2024 年 55 卷 1 期

页码：

收录情况： SCI

摘要： This study aimed at identifying genes associated with loin muscle area (LMA), loin muscle depth (LMD) and backfat thickness (BFT). We performed single-trait and multi-trait genome-wide association studies (GWASs) after genotyping 685 Duroc x (Landrace x Yorkshire) (DLY) pigs using the Geneseek Porcine 50K SNP chip. In the single-trait GWASs, we identified two, eight and two significant SNPs associated with LMA, LMD and BFT, respectively, and searched genes within the 1 Mb region near the significant SNPs with relevant functions as candidate genes. Consequently, we identified one (DOCK5), three (PID1, PITX2, ELOVL6) and three (CCR1, PARP14, CASR) promising candidate genes for LMA, LMD and BFT, respectively. Moreover, the multi-trait GWAS identified four significant SNPs associated with the three traits. In conclusion, the GWAS analysis of LMA, LMD and BFT in a DLY pig population identified several associated SNPs and candidate genes, further deepening our understanding of the genetic basis of these traits, and they may be useful for marker-assisted selection to improve the three traits in DLY pigs.

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