Dietary fatty acids activate or deactivate brown and beige fat

文献类型: 外文期刊

第一作者: Jia, Min

作者: Jia, Min;Xu, Yong-Jiang;Liu, Yuanfa;Jia, Min;Xu, Tongcheng

作者机构:

关键词: Dietary fatty acid; Brown adipocyte; Lipid metabolism; WAT browning; Thermogenesis

期刊名称:LIFE SCIENCES ( 影响因子:6.1; 五年影响因子:5.8 )

ISSN: 0024-3205

年卷期: 2023 年 330 卷

页码:

收录情况: SCI

摘要: Brown adipose tissue (BAT) and beige fat have been documented to rapidly consume fatty acids (FAs) rather than deposit of lipid, and they have high capacity to dissipate energy via nonshivering thermogenesis, making BAT and beige fat potential organs to fight obesity and related chronic diseases. As the main substrate for thermo-genesis and the basic constituent unit of triacylglycerol, FAs could modify BAT and remodel white adipose tissue (WAT) to beige fat. However, there are few comprehensive review covering the link between dietary FAs and thermogenic adipocyte..In this review, we described the metabolism of thermogenic adipose upon activation and comprehensively summarized publications on the dietary FAs that activate or deactivate BAT and beige fat. Specifically, eicosapentaenoic acid/docosahexaenoic acid (EPA/DHA), & alpha;-linolenic acid (& alpha;-ALA), conjugated linoleic acid (CLA), oleic acid (OA), long-chain saturated fatty acid (LC-SFA) and medium-chain fatty acid (MCFA). in addition, the influences on BAT function, WAT remodeling, and lipid metabolism, as well as delin-eated the possible mechanisms are also reviewed. Characterizing thermogenic or obesogenic dietary FAs may offer novel insight into dietary oil and nutritional treatment.

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