Heterogeneity of Intramuscular, Intermuscular, and Subcutaneous Fat in Laiwu Pigs: Insights from Targeted Lipidomics and Transcriptomics

文献类型： 外文期刊

第一作者： Xu, Jian

作者： Xu, Jian;Wu, Tianwen;Yang, Shulin;Wang, Yanfang;Tao, Cong;Lam, Sin Man;Shui, Guanghou

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关键词： Laiwu pig; IMF; backfat; heterogeneity; lipidomics

期刊名称：AGRICULTURE-BASEL （ 影响因子：3.6； 五年影响因子：3.6 ）

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年卷期： 2024 年 14 卷 5 期

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收录情况： SCI

摘要： In the livestock industry, an excessive accumulation of subcutaneous fat diminishes the proportion of lean meat, while elevated intramuscular fat (IMF) content is associated with enhanced meat quality. However, the heterogeneity of various fat depots in pigs remains incompletely understood. Comprehensive tissue section, lipidomic, and transcriptomic analyses indicated that the maturity of IMF was significantly less than that of both intermuscular and subcutaneous fats. We identified 467 lipids across 29 lipid classes in total, revealing that IMF exhibits unique lipid composition and transcriptional profiles. More importantly, several lipids, including GalCer, S1P, CL, AcCa, PC-O, PE-O, and sulfatide, are highly enriched in intramuscular fat and may play pivotal roles in neuromodulation, mitochondrial function, lipogenesis, and membrane signaling. In conclusion, we unveiled unique lipid composition and molecular regulatory pathways of porcine IMF, offering new insights for the synergistic breeding that aims at optimizing pig backfat thickness and IMF content.

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