Luteolin alleviates inorganic mercury-induced liver injury in quails by resisting oxidative stress and promoting mercury ion excretion

文献类型： 外文期刊

第一作者： Liu, Yan

作者： Liu, Yan;Guo, Xinyu;Yu, Lu;Li, Siyu;Yang, Xu;Zhang, Zhigang;Liu, Yan;Huang, Yuxiang;Guo, Changming

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关键词： Luteolin; HgCl2; Liver damage; Oxidative stress; PKC alpha/Nrf2; Excretion of mercury ions

期刊名称：MOLECULAR BIOLOGY REPORTS （ 影响因子：2.742； 五年影响因子：2.702 ）

ISSN： 0301-4851

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收录情况： SCI

摘要： Background Inorganic mercury is a well-known toxic substance that can cause oxidative stress and liver damage. Luteolin (Lut) is a kind of natural antioxidant, which is widely found in plants. Therefore, we focused on exploring the alleviative effect of Lut on liver injury induced by mercuric chloride (HgCl2), and the potential molecular mechanism of eliminating mercury ions in quails. Methods and results Twenty-one-day-old male quails were randomly split into four groups: control group, Lut group, HgCl2 group, and HgCl2 + Lut group. The test period was 12 weeks. The results showed that Lut could significantly ameliorate oxidative stress, the release of inflammatory factors, and liver damage caused by HgCl2, and reduce the accumulation of Hg2+ in quail liver. Furthermore, Lut evidently increased the levels of protein kinase C alpha (PKC alpha), nuclear factor-erythroid-2-related factor 2 (Nrf2), and its downstream proteins, and inhibited nuclear factor-kappaB (NF-kappa B) production in the liver of quails treated by HgCl2. Conclusions To sum up, our results suggest that Lut not only reduces the levels of oxidative stress and inflammation, but also promotes the excretion of Hg2+ by promoting the PKC alpha/Nrf2 signaling pathway to alleviate HgCl2-induced liver injury in quails.

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