Foxtail Millet Improves Blood Glucose Metabolism in Diabetic Rats through PI3K/AKT and NF-kappa B Signaling Pathways Mediated by Gut Microbiota

文献类型： 外文期刊

第一作者： Ren, Xin

作者： Ren, Xin;Wang, Linxuan;Ren, Xin;Hou, Dianzhi;Xue, Yong;Shen, Qun;Chen, Zenglong;Diao, Xianmin

作者机构：

关键词： foxtail millet; glucose metabolism; gut microbiota; PI3K/AKT signaling pathway; NF-kappa B signaling pathway

期刊名称：NUTRIENTS （ 影响因子：5.719； 五年影响因子：6.352 ）

ISSN：

年卷期： 2021 年 13 卷 6 期

页码：

收录情况： SCI

摘要： Foxtail millet (FM) is receiving ongoing increased attention due to its beneficial health effects, including the hypoglycemic effect. However, the underlying mechanisms of the hypoglycemic effect have been underexplored. In the present study, the hypoglycemic effect of FM supplementation was confirmed again in high-fat diet and streptozotocin-induced diabetic rats with significantly decreased fasting glucose (FG), glycated serum protein, and areas under the glucose tolerance test (p < 0.05). We employed 16S rRNA and liver RNA sequencing technologies to identify the target gut microbes and signaling pathways involved in the hypoglycemic effect of FM supplementation. The results showed that FM supplementation significantly increased the relative abundance of Lactobacillus and Ruminococcus_2, which were significantly negatively correlated with FG and 2-h glucose. FM supplementation significantly reversed the trends of gene expression in diabetic rats. Specifically, FM supplementation inhibited gluconeogenesis, stimulated glycolysis, and restored fatty acid synthesis through activation of the PI3K/AKT signaling pathway. FM also reduced inflammation through inhibition of the NF-kappa B signaling pathway. Spearman's correlation analysis indicated a complicated set of interdependencies among the gut microbiota, signaling pathways, and metabolic parameters. Collectively, the above results suggest that the hypoglycemic effect of FM was at least partially mediated by the increased relative abundance of Lactobacillus, activation of the PI3K/AKT signaling pathway, and inhibition of the NF-kappa B signaling pathway.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序