paper Copy number variation (CNV) of the AHR gene in the Ashidan yak and its association with growth traits

文献类型： 外文期刊

第一作者： Dai, Rongfeng

作者： Dai, Rongfeng;Huang, Chun;Wu, Xiaoyun;Ma, Xiaoming;Chu, Min;Bao, Pengjia;Pei, Jie;Guo, Xian;Yan, Ping;Liang, Chunnian

作者机构：

关键词： Copy number variation (CNV); AHR gene; Ashidan yak; Growth trait; Associative analysis

期刊名称：GENE （ 影响因子：3.913； 五年影响因子：3.48 ）

ISSN： 0378-1119

年卷期： 2022 年 826 卷

页码：

收录情况： SCI

摘要： Copy number variation (CNV) is a principal genomic structure variation affecting the gene expression through the dose-effect and change of gene regulatory region. It plays an important role in regulating the various complex traits of vertebrates. The aromatic hydrocarbon receptor (AHR) is a member of ligand-dependent transcription factors which belong to the alkaline helix-loop-helix PASS family. It is used as a conservative environmental sensor during biological evolution. This study, tracked the growth data (body weight, withers height, body length, chest girth) of 332 yaks in four stages (6, 12, 18, and 30 months) were tracked. The CNV of the yaks was analyzed using real-time quantitative PCR, and the correlation between CNV of AHR and yak growth traits was analyzed using the SPSS and R software. The AHR gene expression profiles were assessed in different tissues of the 18-month-old yak. The statistical analysis indicated the AHR-CNV of the Ashidan yak to significantly correlate with the body length (P < 0.05), and was found to be correlated with the withers height at 18 months old (P < 0.01) with extreme significance. To sum up, this study for the first time discussed the relationship between AHR-CNV and the growth traits of the Ashidan yak. The results indicated that the AHR gene might become a new molecular marker in the breeding yak.

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