Carboline derivatives based on natural pityriacitrin as potential antifungal agents

文献类型： 外文期刊

第一作者： Huang, Daye

作者： Huang, Daye;Zhang, Zhigang;Liu, Fang;Huang, Wenbo;Min, Yong;Wang, Kaimei;Yang, Jingzhong;Cao, Chunxia;Gong, Yan;Ke, Shaoyong;Huang, Daye;Zhang, Zhigang;Liu, Fang;Huang, Wenbo;Min, Yong;Wang, Kaimei;Yang, Jingzhong;Cao, Chunxia;Gong, Yan;Ke, Shaoyong;Li, Yanyan

作者机构：

关键词： Carboline alkaloids; Carboline derivatives; Antifungal activity; Broad-spectrum

期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.873； 五年影响因子：1.875 ）

ISSN： 1874-3900

年卷期： 2022 年 48 卷

页码：

收录情况： SCI

摘要： Carboline alkaloids are a class of important heterocyclic natural products, which usually present extensive bioactivities. During the course of our research for active compounds from natural products, the pityriacitrin and pityriacitrin B belonged carboline alkaloids have been isolated from a Chinese Burkholderia sp. NBF227, which indicated potential antifungal activities. So, in order to develop these carboline alkaloids as potential fungicidal agents, a series of pityriacitrin derivatives were investigated for their antifungal activities against Phytophthora capsici, Sclerotinia sclerotiorum, Botrytis cinerea and Rhizoctonia solani, and the results demonstrated that com-pounds 4, 10 and 19 displayed broad-spectrum antifungal activities. In addition, in vivo bioassay also indicated that compounds 4 and 10 could protect the pepper leaves and grape fruits against infection by P. capsici and B. cinerea, respectively. The possible mechanism of antifungal action for these compounds was also explored.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序