Similarities and Differences of Autophagy in Mammals, Plants, and Microbes

文献类型： 外文期刊

第一作者： Lin, Fu-Cheng

作者： Lin, Fu-Cheng;Shi, Huan-Bin;Liu, Xiao-Hong

作者机构：

期刊名称：AUTOPHAGY: BIOLOGY AND DISEASES: TECHNOLOGY AND METHODOLOGY （ 影响因子：2.622； 五年影响因子：3.049 ）

ISSN： 0065-2598

年卷期： 2021 年 1208 卷

页码：

收录情况： SCI

摘要： Autophagy, a highly conserved metabolic process in eukaryotes, is a widespread degradation/recycling system. However, there are significant differences (as well as similarities) between autophagy in animals, plants, and microorganisms such as yeast. While the overall process of autophagy is similar between different organisms, the molecular mechanisms and the pathways regulating autophagy are different, which is manifested in the diversity and specificity of the genes involved. In general, the autophagy system is much more complicated in mammals than in yeast. In addition, there are some differences in the types of autophagy present in animals, plants, and microorganisms. For example, there is a unique type of selective autophagy called the cytoplasm-to-vacuole targeting (Cvt) pathway in yeast, and a special kind of autophagy, chloroplast autophagy, exists in plants. In conclusion, although autophagy is highly conserved in eukaryotes, there are still many differences between autophagy of animals, plants, and microorganisms.

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