The fate of recent duplicated genes following a fourth-round whole genome duplication in a tetraploid fish, common carp (Cyprinus carpio)

文献类型： 外文期刊

第一作者： Li, Jiong-Tang

作者： Li, Jiong-Tang;Hou, Guang-Yuan;Kong, Xiang-Fei;Li, Chun-Yan;Zeng, Jian-Ming;Li, Heng-De;Xiao, Gui-Bao;Li, Xiao-Min;Sun, Xiao-Wen;Li, Jiong-Tang;Hou, Guang-Yuan;Kong, Xiang-Fei;Li, Chun-Yan;Zeng, Jian-Ming;Li, Heng-De;Xiao, Gui-Bao;Li, Xiao-Min;Sun, Xiao-Wen;Kong, Xiang-Fei;Li, Chun-Yan;Li, Chun-Yan;Xiao, Gui-Bao;Li, Xiao-Min

作者机构：

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2015 年 5 卷

页码：

收录情况： SCI

摘要： Whole genome duplication (WGD) results in extensive genetic redundancy. In plants and yeast, WGD is followed by rapid gene deletions and intense expression differentiation with slow functional divergence. However, the early evolution of the gene differentiation processes is poorly understood in vertebrates because almost all studied WGDs are extremely ancient, and the genomes have returned to a diploid status. Common carp had a very recent fourth round ofWGD dated to 8 million years ago. It therefore constitutes an ideal model to study early-stage functional divergence and expression differentiation in vertebrates. We identified 1,757 pairs of recently duplicated genes (RDGs) originating from this specific WGD and found that most ancestral genes were retained in duplicate. Most RDGs were conserved and under selective pressure. Gene expression analysis across six tissues revealed that 92.5% of RDG pairs were co-expressed in at least one tissue and that the expression of nearly half pairs ceased to be strongly correlated, indicating slow spatial divergence but rapid expression dissociation. Functional comparison revealed that 25% of pairs had functional divergence, of which neo- and sub-functionalization were the main outcomes. Our analysis revealed slow gene loss but rapid and intense expression and function differentiation after WGD.

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