Fates of bioactive compounds and antioxidant activities of red pitaya pulp upon in vitro gastrointestinal digestion

文献类型： 外文期刊

第一作者： Lin, Xian

作者： Lin, Xian;Li, Xiangyu;Huang, Ying;Wen, Jing;Yu, Yuanshan;Tang, Daobang;Xu, Yujuan;Lin, Xian;Xu, Baojun;Lin, Xian

作者机构：

关键词： Red pitaya; Gastrointestinal digestion; Bioactive compound; Antioxidant activity

期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：8.0； 五年影响因子：8.5 ）

ISSN： 0963-9969

年卷期： 2025 年 200 卷

页码：

收录情况： SCI

摘要： Health benefit effects of bioactive compounds depend on their bioavailabilities, which could vary according to factors including food matrix and digestion environment. To understand the "bioaccessible" health benefit of red pitay pulp, the INFOGEST static in vitro simulation of gastrointestinal (GI) digestion model and targeted metabolomics method were applied to unravel the fates of bioactive compounds in the whole food of red pitaya pulp during GI digestion. The antioxidant activity as one of the health benefit indices was also assessed to compare the changes in bioactive properties of red pitaya pulp. Results showed that, after GI digestion, total phenolic and flavonoid content increased by 84% and 4.55 folds, respectively. But total betacyanin content decreased. All the detected phenolic acids increased during the GI process, and lots of new phenolic compounds were produced. The overall chemical antioxidant capacity of red pitaya pulp increased after GI digestion. Correlation analysis results indicated that flavonoids and ferulic acid were probably the primary sources of the antioxidant capacity of the red pitaya pulp and its digests. Moreover, the cytoprotective effects against H2O2induced oxidative damage varied among gastric cell, enterocyte and hepatocyte. The GI digests of red pitaya pulp could better alleviate the H2O2-induced oxidative stress in cells by preventing the increase of reactive oxygen species (ROS), inhibiting the production of malondialdehyde (MDA), increasing the production of glutathione (GSH), and promoting the activities of catalase (CAT) and superoxide dismutase (SOD). These findings can be used as a basis for future studies in the design and production of functional ingredients/foods.

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