Phosphine-Catalyzed Asymmetric Tandem Isomerization/Annulation of Allyl Amines with Allenoates: Enantioselective Annulation of a Saturated C-N Bond

文献类型： 外文期刊

第一作者： Zhou, Leijie

作者： Zhou, Leijie;Wang, Qijun;Liu, Min;Guo, Hongchao;Zhou, Leijie;Wang, Qijun;Liu, Min;Guo, Hongchao;Zhang, Xue;Wang, Wei;Wu, Yongjun;Chen, Liezhong

作者机构：

期刊名称：ORGANIC LETTERS （ 影响因子：6.072； 五年影响因子：5.592 ）

ISSN： 1523-7060

年卷期： 2021 年 23 卷 23 期

页码：

收录情况： SCI

摘要： Under catalysis by chiral phosphine, an asymmetric isomerization/annulation cascade reaction of allylamines with allenoates was realized. A wide range of gamma-substituted allenoates were tolerated to afford chiral pyrroline derivatives in high yields with excellent enantioselectivities. In the reaction, isomerization of readily available N-allylamines to reactive aliphatic imines through a 1,4-proton shift is a key step, which circumvents the isolation of highly unstable alkyl N-sulfonylimines.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序