Proteomic and antimicrobial peptide analyses of Buffalo colostrum and mature Milk whey: A comparative study

文献类型： 外文期刊

第一作者： Liu, Runfeng

作者： Liu, Runfeng;Yang, Yuan;Zhang, Yue;Sun, Qinqiang;Zhu, Pingchuan;Xu, Huiyan;Lu, Yangqing;Fu, Qiang;Zheng, Wei

作者机构：

关键词： Buffalo colostrum; Whey protein; Proteomics; Mass spectrometry; Antimicrobial peptides

期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）

ISSN： 0308-8146

年卷期： 2024 年 448 卷

页码：

收录情况： SCI

摘要： Buffalo colostrum is the initial mammary secretion after parturition, consisting of nutritional and bioactive components. In this study, we conducted a proteomic analysis of buffalo colostrum whey to identify bioactive proteins and peptides. A total of 107 differentially expressed proteins (DEPs) were identified in buffalo colostrum whey compared to those in mature milk. Gene Ontology analysis revealed that DEPs were primarily associated with immune response and tissue development. KEGG pathway enrichment suggested that colostrum actively enhances nascent immunity involved in interleukin and interferon signaling pathways. Furthermore, candidate antimicrobial peptides (AMPs) of whey protein hydrolysates from buffalo colostrum were characterized, which exhibits broad-spectrum activity against gram-positive and gram-negative pathogens. Overall, this study improves our understanding of protein variations in buffalo lactation, and contributes to the development of AMPs from buffalo colostrum.

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