Discover QTLs for the level of blood components in Shaoxing duck using GWAS and haplotype sharing analysis

文献类型： 外文期刊

第一作者： Xu, Wenwu

作者： Xu, Wenwu;Tao, Zeng;Lu, Lizhi;Xu, Wenwu;Wang, Zhenzhen;Tao, Zeng;Lu, Lizhi;Li, Kui

作者机构：

关键词： GWAS; haplotype; blood components; Shaoxing duck

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：1.7； 五年影响因子：1.9 ）

ISSN： 1049-5398

年卷期： 2024 年 35 卷 1 期

页码：

收录情况： SCI

摘要： Blood composition is indicative of health-related traits such as immunity and metabolism. The use of molecular genetics to investigate alterations in these attributes in laying ducks is a novel approach. Our objective was to employ genome - wide association studies (GWAS) and haplotype - sharing analysis to identify genomic regions and potential genes associated with 11 blood components in Shaoxing ducks. Our findings revealed 35 SNPs and 1 SNP associated with low-density lipoprotein cholesterol (LDL) and globulin (GLB), respectively. We identified 36 putative candidate genes for the LDL trait in close proximity to major QTLs and key loci. Based on their biochemical and physiological properties, TRA2A, NPY, ARHGEF26, DHX36, and AADAC are the strongest putative candidate genes. Through linkage disequilibrium analysis and haplotype sharing analysis, we identified three haplotypes and one haplotype, respectively, that were significantly linked with LDL and GLB. These haplotypes could be selected as potential candidate haplotypes for molecular breeding of Shaoxing ducks. Additionally, we utilized a bootstrap test to verify the reliability of GWAS with small experimental samples. The test can be accessed at https://github.com/xuwenwu24/Bootstrap-test.

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