Bioactive polyhydroxylated sterols from the marine sponge Haliclona crassiloba

文献类型: 外文期刊

第一作者: Cheng, Zhong-Bin

作者: Cheng, Zhong-Bin;Xiao, Han;Zhang, Ge;Yin, Sheng;Fan, Cheng-Qi;Lu, Ya-Nan

作者机构:

关键词: Polyhydroxylated sterols;Structure elucidation;Antibacterial activity;Haliclona crassiloba

期刊名称:STEROIDS ( 影响因子:2.668; 五年影响因子:2.692 )

ISSN: 0039-128X

年卷期: 2013 年 78 卷 14 期

页码:

收录情况: SCI

摘要: Four new polyhydroxylated sterols, named halicrasterols A-D (1-4), together with six known analogs (5-10) were isolated from the marine sponge Haliclona crassiloba. Compounds 1 and 2 represented rare examples of steroids featuring 17(20)E-double bonds. The structures of 1-10 were elucidated by spectroscopic analysis and comparison with reported data. This is the first report of a steroid profile for this species. The antimicrobial activities of 1-10 were evaluated against a panel of bacterial and fungal strains in vitro, and compounds 4 and 9 showed moderate activity against some of the Gram-positive strains with MICs ranging from 4 to 32 mu g/mL. (C) 2013 Elsevier Ltd. All rights reserved.

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