Nitrogen Mustard Based 2-Benzylidene-1-tetralone as ICT-Based Fluorescent Probe for Drug Release Monitoring and Cervical Cancer Therapy

文献类型： 外文期刊

第一作者： Liang, Yuanwei

作者： Liang, Yuanwei;Li, Chengpeng;Qiu, Wenhua;Li, Puwang;Yang, Ziming;Lin, Haisheng;Zhao, Yuntao;Lin, Haisheng;Zhao, Yuntao

作者机构：

关键词： nitrogen mustard; drug release; fluorescent probe; cancer therapy

期刊名称：RUSSIAN JOURNAL OF GENERAL CHEMISTRY （ 影响因子：0.779； 五年影响因子：0.697 ）

ISSN： 1070-3632

年卷期： 2022 年 92 卷 11 期

页码：

收录情况： SCI

摘要： A series of novel intramolecular charge transfer (ICT) based 2-benzylidene-1-tetralones that contain nitrogen mustard for drug release monitoring and cervical cancer therapy were developed. Their emission wavelength and Stokes shift were up to 550 nm and 142 nm, respectively. These compounds exerted excellent anticancer activity against cervical cancer cells, among which 2-{4-[bis(2-chloroethyl)amino]benzylidene}-7-fluoro-3,4-dihydronaphthalen-1(2H)-one exerted the strongest anti-proliferation activity that inhibited HeLa cell cycle in G(2)/M phase and induced cell apoptosis, as well as activating pro-apoptotic proteins. Furthermore, the release of 2-{4-[bis(2-chloroethyl)amino]benzylidene}-7-fluoro-3,4-dihydronaphthalen-1(2H)-one probe was monitored to locate in lysosomes and nuclei.

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