The Impact of Novel BMPR1B Mutations on Litter Size in Short-Tailed Gobi Sheep and Larger-Tailed Ujimqin Sheep

文献类型： 外文期刊

第一作者： Bai, Yanyu

作者： Bai, Yanyu;Cang, Ming;Tong, Bin;Wang, Shenyuan;Wu, Kaifeng;Zhang, Ming;Alatan, Suhe;Cao, Guifang;Jin, Hai;Li, Changqing

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关键词： BMPR1B; litter size; Gobi short tail sheep; Ujimqin sheep; T/Brachyury

期刊名称：VETERINARY SCIENCES （ 影响因子：2.0； 五年影响因子：2.2 ）

ISSN：

年卷期： 2024 年 11 卷 7 期

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收录情况： SCI

摘要： The significant deposition of tail fat in sheep has a profound impact on the economic benefits of animal husbandry. Furthermore, increasing the litter size is a crucial means of enhancing economic benefits. The BMPR1B and T/Brachyury genes are considered major functional genes that could affect sheep litter size and tail bone number, respectively. In this study, we employed direct sequencing to identify specific mutations of the BMPR1B gene in Gobi short tail sheep and carried out genotyping using MassARRAY technology for each variant of both the BMPR1B and T genes. Significant associations were demonstrated between the c.687G>A mutation of BMPR1B and the litter size in both the Gobi short tail sheep and Ujimqin sheep breeds. Meanwhile, the g.30058882_30058873GCAGATTAAAIndel mutation was significantly associated with the litter size in Gobi short tail sheep. These findings may provide valuable genetic markers for expanding sheep litter size. In addition, we also confirmed that the frequency of tail-bone-number-related T alleles was significantly higher in Gobi short tail sheep than in longer-tailed Ujimqin sheep.

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