Simultaneous quantification of oxyclozanide and levamisole in milk via ultra-high-performance liquid chromatography tandem mass spectrometry: A validated high-sensitivity approach for veterinary residue surveillance
文献类型： 外文期刊
第一作者： Dai, G.
作者： Dai, G.;Sun, K.;Zhou, Y.;Li, B.;Wang, Q.;Qiu, Y.;Zhou, X.;Zhang, J.;Dai, G.;Sun, K.;Zhang, J.;Peng, X.
作者机构：
关键词： veterinary drug residues; UPLC-MS/MS; food safety; antiparasitic agents; milk
期刊名称：JOURNAL OF DAIRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）
ISSN： 0022-0302
年卷期： 2025 年 108 卷 8 期
页码：
收录情况： SCI
摘要： This study developed a novel analytical method integrating liquid-liquid extraction with solid-phase extraction for simultaneous detection of oxyclozanide (OXY) and levamisole hydrochloride (LMS) residues in milk using ultra-high-performance liquid chromatography tandem MS (UPLC-MS/MS). Method validation demonstrated exceptional sensitivity with detection limits of 1.00 ng/mL and quantitation limits of 3.00 ng/mL for both analytes. Low matrix effects (CV <8.00%) and satisfactory recoveries (OXY: 84.00%-108.77%, relative SD [RSD]: 2.20%-8.00%; LMS: 89.50%-119.60%, RSD: 2.10%-8.36%) were achieved across multiple validation parameters, while sample stability remained consistent under varied processing conditions (CV <10.00%). Analysis of 120 commercial milk samples revealed no detectable residues, confirming both the reliability of this monitoring framework and the compliance of Chinese dairy products with international safety standards. As the first reported method enabling concurrent detection of this antiparasitic drug combination, the established protocol provides crucial technical support for veterinary drug residue surveillance, ensuring safer application of compound oxyclozanide suspension in livestock husbandry.
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