Integration of multi-omics reveals the important role of the BBS10 gene in reproduction

文献类型： 外文期刊

第一作者： Zhang, Guoqing

作者： Zhang, Guoqing;Chu, Mingxing;Feng, Pingjie;Shi, Jianxin;Li, Hao;Li, Xinyue;Pan, Zhangyuan;Wang, Shoufeng

作者机构：

关键词： Bardet-Biedl syndrome; BBS10; glutathione metabolism; metabonomics; sheep; Transcriptomics

期刊名称：JOURNAL OF ANIMAL SCIENCE （ 影响因子：2.9； 五年影响因子：3.3 ）

ISSN： 0021-8812

年卷期： 2024 年 102 卷

页码：

收录情况： SCI

摘要： Blood samples are easily obtained from sheep. Therefore, blood analysis can be a convenient method for evaluating reproductive traits in sheep by detecting genetic and metabolic changes in the ovary. By combining 167 RNA sequencing data and 60 untargeted metabolomics data, this study analyzed the relationship between genes and metabolites in the ovary and blood. The conjoint KEGG enrichment analysis enriched glutathione (GSH) metabolic pathways both in the ovary and blood. This finding provides an explanation for possible GSH metabolic processes in the ovary with metabolite exchange in the blood. The metabolite-gene-disease interaction network revealed a correlation between the expression of certain Bardet-Biedl syndrome (BBS) family genes in the ovary and blood. This indicates that BBS family genes, such as BBS10 in sheep blood, could be a potential biomarker for BBS. We investigated the relationship between BBS10 gene expression in the ovary and lambing numbers using whole-genome sequencing data from 450 ewes. Our findings suggest that g.112314188C>G may lead to decreased litter size in ewes carrying the FecB gene. These single nucleotide polymorphisms could be potential molecular markers for breeding sheep.

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