Prostaglandin E-2 and insulin-like growth factor I interact to enhance proliferation of theca externa cells from chicken prehierarchical follicles
文献类型: 外文期刊
第一作者: Jia, Yudong
作者: Jia, Yudong;Lin, Jinxing;Mi, Yuling;Zhang, Caiqiao;Jia, Yudong;Lin, Jinxing
作者机构:
关键词: Theca externa cell;Prostaglandin E-2;Insulin-like growth factor I;Prehierarchical follicle;Chicken
期刊名称:PROSTAGLANDINS & OTHER LIPID MEDIATORS ( 影响因子:3.072; 五年影响因子:3.393 )
ISSN: 1098-8823
年卷期: 2013 年 106 卷
页码:
收录情况: SCI
摘要: The interactive effect of insulin-like growth factor I (IGF-I) and prostaglandin E-2 (PGE(2)) on the proliferation of theca externa cells (TECs) was investigated in the prehieraichical small yellow follicles of laying hens. IGF-I manifested a proliferating effect like PGE(2) on TECs, but this stimulating effect was restrained by AG1024 (IGF-IR inhibitor), KP372-1 (PKB/AKT inhibitor) or NS398 (COX-2 inhibitor). AG1024, KP372-1 or NS398 abolished IGF-I-stimulated COX-2 expression and PGE(2) production. Meanwhile, KP372-1, NS398 or AG1024 depressed the PGE(2)-stimulated expression of COX-2 and IGF-IR mRNA. Therefore, the IGF-I receptor pathway up-regulates COX-2 expression and PGE(2) synthesis via PKB signaling cascade, and then PGE(2) stimulates IGF-IR mRNA expression to promote TEC proliferation in an autocrine pattern. Overall, the reciprocal stimulation of intracellular PGE(2) and IGF-I may enhance TEC proliferation and facilitate the development of chicken prehierarchical follicles. (C) 2013 Elsevier Inc. All rights reserved.
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