Nanoliposome based strategy for enhancing bioavailability and antitumor activity of polyphenol from Sanghuangporus vaninii

文献类型： 外文期刊

第一作者： Liu, Peng

作者： Liu, Peng;Wang, Yuyang;Zhang, Zhong;Wu, Di;Chen, Wanchao;Li, Wen;Yang, Yan;Liu, Peng;Wang, Yuyang;Zhang, Zhong;Wu, Di;Chen, Wanchao;Li, Wen;Yang, Yan;Liu, Peng;Liu, Junbo;Wang, Weike

作者机构：

关键词： Sanghuangporus vaninii; Nanoliposome; Liver tumor; Polyphenol; Bioavailability

期刊名称：FOOD BIOSCIENCE （ 影响因子：5.9； 五年影响因子：6.1 ）

ISSN： 2212-4292

年卷期： 2025 年 63 卷

页码：

收录情况： SCI

摘要： Sanghuangporus vaninii as a valuable edible fungus represents a high source of polyphenols with multidimensional bioactivities. However, the conundrum of the oral bioavailability of polyphenols limits its biological activity. Therefore, a strategy of nanoliposome was employed to enhance oral bioavailability of polyphenols from S. vaninii. In this study, a polyphenol component (PV5) with excellent inhibition of HepG2 cells was isolated and purified from S. vaninii. For enhancing bioavailability and bioactivity of PV5, nanoliposomes-loaded with PV5 (PV5-NPs) with an average particle size of (110.17 +/- 2.01) nm were prepared, and improved the oral bioavailability of PV5 in vivo. Additionally, PV5-NPs synergistically enhanced the antitumor activity in the H22 tumor bearing mice, reflecting in reducing tumor size and increasing levels of pro-apoptotic factors. The mechanism of PV5-NPs against liver tumor might be attributed to the blocking MEK/ERK pathway. The bioactive agents of PV5 such as Phellibaumin A, Phelligridin_C and Hispidin played a key role in the antitumor activity. Consequently, this study indicated that nanoliposomes could be used as a potential strategy for elevating bioavailability and bioactivity of polyphenols from S. vaninii.

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