Crosstalk between trace elements and T-cell immunity during early-life health in pigs

文献类型： 外文期刊

第一作者： He, Liuqin

作者： He, Liuqin;Li, Jianzhong;Jin, Shunshun;Yang, Chenbo;He, Liuqin;Li, Tiejun;He, Xinmiao;Chen, Heshu;Feng, Yanzhong;Liu, Di;Tang, Wenjie

作者机构：

关键词： trace elements; T cells; pig; gut; immunity

期刊名称：SCIENCE CHINA-LIFE SCIENCES （ 影响因子：9.1； 五年影响因子：7.1 ）

ISSN： 1674-7305

年卷期： 2023 年

页码：

收录情况： SCI

摘要： With gradual ban on the use of antibiotics, the deficiency and excessive use of trace elements in intestinal health is gaining attention. In mammals, trace elements are essential for the development of the immune system, specifically T-cell proliferation, and differentiation. However, there remain significant gaps in our understanding of the effects of certain trace elements on T-cell immune phenotypes and functions in pigs. In this review, we summarize the specificity, development, subpopulations, and responses to pathogens of porcine T cells and the effects of functional trace elements (e.g., iron, copper, zinc, and selenium) on intestinal T-cell immunity during early-life health in pigs. Furthermore, we discuss the current trends of research on the crosstalk mechanisms between trace elements and T-cell immunity. The present review expands our knowledge of the association between trace elements and T-cell immunity and provides an opportunity to utilize the metabolism of trace elements as a target to treat various diseases.

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