文献类型： 外文期刊
第一作者： Zhai, Lijuan
作者： Zhai, Lijuan;Sun, Jian;Zhou, Pengjuan;Ji, Jingwen;He, Lili;Tang, Dong;Ji, Jinbo;Yang, Haikang;Iqbal, Zafar;Yang, Zhixiang
作者机构：
关键词： kukoamine A; natural product; dihydrocaffeic acid; spermine
期刊名称：CHEMISTRY OF NATURAL COMPOUNDS （ 影响因子：0.8； 五年影响因子：0.8 ）
ISSN： 0009-3130
年卷期： 2024 年
页码：
收录情况： SCI
摘要： Kukoamine A has been known for decades as an anti-inflammatory and hypotensive principle of Chinese medicinal plant extract from Lycium root, bark, and fruit. The recent pharmacological significance of this alkaloid makes it a potential therapeutic target for the pharmaceutical industry. We accomplished the synthesis of kukoamine A in a 73% yield over four steps starting from cheaper commercial reagents, ambient reaction conditions, and minimal purification efforts.
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