Improving the xanthine oxidase and adenosine deaminase inhibitory activities of Flos Sophorae Immaturus by ultrasound-assisted heating treatments

文献类型： 外文期刊

第一作者： Li, Jun

作者： Li, Jun;Gong, Yuhong;Li, Jinwei;Fan, Liuping;Li, Jinwei;Fan, Liuping;Fan, Liuping;Li, Jun;Fan, Liuping

作者机构：

关键词： Anti-xanthine oxidase activity; Anti -adenosine deaminase activity; Flos Sophorae Immaturus; Flavones; Ultrasound treatment; Heating treatment

期刊名称：FOOD BIOSCIENCE （ 影响因子：5.2； 五年影响因子：5.4 ）

ISSN： 2212-4292

年卷期： 2023 年 51 卷

页码：

收录情况： SCI

摘要： Flos Sophorae Immaturus (FSI) is consumed as a natural food rich in flavonoids and exhibits potential xanthine oxidase (XOD) and adenosine deaminase (ADA) inhibitory activities. Therefore, ultrasound and heating treat-ments were applied to improve the XOD and ADA inhibitory effects of FSI, and the mechanisms were revealed by tracking the changes of flavones. Results showed that ultrasound (480 W, 60 min) assisted heating treatments (180 degrees C, 60 min) significantly improved the XOD (from 40.97% to 83.47%) and ADA (6.64%-23.28%) inhibition rates. Meanwhile, ultrasound and heat treatment caused significant variations in total polyphenols and flavonoid contents and altered the flavonoid composition of FSI. Specifically, rutin, kaempferol-3-o-rutinoside, and nar-cissoside of FSI converted to quercetin, kaempferol, and isorhamnetin during heating treatments. However, the model experiment revealed that ultrasound treatment did not cause the conversion of flavones and just promoted the dissolution of FSI flavones. Furthermore, quercetin, kaempferol, and isorhamnetin possessed better XOD and ADA inhibitory activities than rutin, kaempferol-3-o-rutinoside, and narcissoside at a concentration from 0.025 mg/mL to 1.0 mg/mL, implying de-glycosylation is a feasible approach for enhancing XOD and ADA activity. The present study provides a promising strategy for the processing of FSI.

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