Jute (Corchorus olitorius L.) Nanocrystalline Cellulose Inhibits Insect Virus via Gut Microbiota and Metabolism

文献类型： 外文期刊

第一作者： Deng, Yanchun

作者： Deng, Yanchun;Yang, Xiai;Chen, Jiquan;Chi, Haiyang;Chen, Chenxiao;Yang, Xiushi;Hou, Chunsheng;Yang, Sa;Yang, Sa

作者机构：

关键词： Corchorus capsularis L; nanocrystallinecellulose; IAPV; gut microbiota; metabolism; immune

期刊名称：ACS NANO （ 影响因子：17.1； 五年影响因子：17.1 ）

ISSN： 1936-0851

年卷期： 2023 年 17 卷 21 期

页码：

收录情况： SCI

摘要： Natural plant nanocrystalline cellulose (NCC), exhibiting a number of exceptional performance characteristics, is widely used in food fields. However, little is known about the relationship between NCC and the antiviral effect in animals. Here, we tested the function of NCC in antiviral methods utilizing honey bees as the model organism employing Israeli acute paralysis virus (IAPV), a typical RNA virus of honey bees. In both the lab and the field, we fed the IAPV-infected bees various doses of jute NCC (JNCC) under carefully controlled conditions. We found that JNCC can reduce IAPV proliferation and improve gut health. The metagenome profiling suggested that IAPV infection significantly decreased the abundance of gut core bacteria, while JNCC therapy considerably increased the abundance of the gut core bacteria Snodgrassella alvi and Lactobacillus Firm-4. Subsequent metabolome analysis further revealed that JNCC promoted the biosynthesis of fatty acids and unsaturated fatty acids, accelerated the purine metabolism, and then increased the expression of antimicrobial peptides (AMPs) and the genes involved in the Wnt and apoptosis signaling pathways against IAPV infection. Our results highlighted that JNCC could be considered as a prospective candidate agent against a viral infection.

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