Genome assembly and transcriptome analysis provide insights into the antischistosome mechanism of Microtus fortis

文献类型： 外文期刊

第一作者： Li, Hong

作者： Li, Hong;Wang, Zhen;Xiao, Qingyu;Miao, Benpeng;Lin, Weili;Li, Yixue;Chai, Shumei;Huang, Mingyue;Lin, Jiaojiao;Fu, Zhiqiang;Bai, Xiong;Feng, Jie;Gao, Cheng;Xie, Jianyun;Ding, Guohui;Li, Yuanyuan;Li, Yixue;Li, Junyi;Li, Bin;Hu, Wei;Li, Yixue

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关键词： Genome assembly; Microtus fortis; Schistosome; Immune; Transcriptome

期刊名称：JOURNAL OF GENETICS AND GENOMICS （ 影响因子：5.723； 五年影响因子：5.755 ）

ISSN： 1673-8527

年卷期： 2020 年 47 卷 12 期

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收录情况： SCI

摘要： Microtus fortis is the only mammalian host that exhibits intrinsic resistance against Schistosoma japonicum infection. However, the underlying molecular mechanisms of this resistance are not yet known. Here, we perform the first de novo genome assembly of M. fortis, comprehensive gene annotation analysis, and evolution analysis. Furthermore, we compare the recovery rate of schistosomes, pathological changes, and liver transcriptomes between M. fortis and mice at different time points after infection. We observe that the time and type of immune response in M. fortis are different from those in mice. M. fortis activates immune and inflammatory responses on the 10th day post infection, such as leukocyte extravasation, antibody activation, Fc-gamma receptor-mediated phagocytosis, and the interferon signaling cascade, which play important roles in preventing the development of schistosomes. In contrast, an intense immune response occurrs in mice at the late stages of infection and could not eliminate schistosomes. Infected mice suffer severe pathological injury and continuous decreases in cell cycle, lipid metabolism, and other functions. Our findings offer new insights into the intrinsic resistance mechanism of M. fortis against schistosome infection. The genome sequence also provides the basis for future studies of other important traits in M. fortis. Copyright (C) 2021, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.

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