Combined approaches identify known and novel genes associated with sheep litter size and non-seasonal breeding

文献类型： 外文期刊

第一作者： Tao, Lin

作者： Tao, Lin;Wang, Xiangyu;Zhong, Yingjie;Xia, Qing;Chen, Si;He, Xiaoyun;Di, Ran;Chu, Mingxing;Liu, Qiuyue

作者机构：

关键词： BMPR1B; litter size; Ovis aries; seasonal breeding; TSHR

期刊名称：ANIMAL GENETICS （ 影响因子：3.169； 五年影响因子：3.058 ）

ISSN： 0268-9146

年卷期： 2021 年 52 卷 6 期

页码：

收录情况： SCI

摘要： Improvement of ewe reproduction is considerable by appropriately increasing litter size and sustaining non-seasonal breeding. However, their genetic makeups have not been entirely elucidated. Genome-wide analyses of 821 individuals were performed by combining three genomic approaches (genome-wide association study, XP-nSL, and runs of homozygosity). Consequently, 35 candidate genes including three domestication genes (TSHR, GTF2A1, and KITLG) were identified. Other than the FecB mutation at BMPR1B, we described a significant association of a missense mutation rs406686139 at seasonal lambing-associated TSHR gene with litter size. Some promising novel genes may be relevant for sheep reproduction by multitude biological processes, such as FETUB functioning in fertilization, HNRNPA1 in oogenesis, DCUN1D1 in spermatogenesis, and HRG in fertility outcome. The present study suggests that improvement of ewe reproduction is attributed to selective breeding, and casts light on the genetic basis and improvement of sheep reproduction.

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