Swainsonine producing performance of Alternaria oxytropis was improved by heavy-ion mutagenesis technology

文献类型： 外文期刊

第一作者： Liang, Yan

作者： Liang, Yan;Zhi, Dejuan;Wang, Zhen;Li, Shangwei;Song, Xiangdong;Zhou, Deshun;Hao, Baocheng;Liu, Yu;Liang, Jianping

作者机构：

关键词： swainsonine; Alternaria oxytropis; mutant; heavy-ion; irradiation; mutagenesis

期刊名称：FEMS MICROBIOLOGY LETTERS （ 影响因子：2.742； 五年影响因子：2.856 ）

ISSN： 0378-1097

年卷期： 2021 年 368 卷 8 期

页码：

收录情况： SCI

摘要： Swainsonine, an indolizidine alkaloid, is a promising anti-tumorigenic compound. Biological production of swainsonine was prospective, but the low swainsonine yield of wild type Alternaria oxytropis limited its production on a large scale. In present work, a stable A. oxytropis mutant UO1 with swanisonine yield of 14.84% higher than the wild-type strain was successfully obtained after heavy-ion irradiation. The A. oxytropis mutant UO1 and original wild-type strain were futher evaluated for SW concentrations under different factors. Results showed that the optimum culture temperature was 25 degrees C. The optimum initial medium pH was 6.5 and the optimum inoculum size was 2 mL per 200 mL. Addition of the biosynthetic precursor L-pipecolic acids and L-lysine appropriately could increase the SW synthesis. These findings provided a theoretical basis and scientific data for the industrial production of swainsonine.

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