OsBCAT2, a gene responsible for the degradation of branched-chain amino acids, positively regulates salt tolerance by promoting the synthesis of vitamin B5

文献类型： 外文期刊

第一作者： Sun, Yangyang

作者： Sun, Yangyang;Long, Qiyuan;Liu, Yanchen;Zhang, Changjian;Zhang, Yuanyuan;Luo, Yuehua;Luo, Jie;Jin, Cheng;Sun, Yangyang;Zhou, Yutong;Long, Qiyuan;Xing, Junwei;Guo, Peizhen;Liu, Yanchen;Zhang, Changjian;Zhang, Yuanyuan;Luo, Yuehua;Jin, Cheng;Sun, Yangyang;Fernie, Alisdair R.;Shi, Yuheng;Luo, Jie

作者机构：

关键词： branched-chain amino acids; degradation; rice; salt; vitamin B5

期刊名称：NEW PHYTOLOGIST （ 影响因子：9.4； 五年影响因子：10.5 ）

ISSN： 0028-646X

年卷期： 2024 年 241 卷 6 期

页码：

收录情况： SCI

摘要： center dot Salt stress negatively affects rice growth, development and yield. Metabolic adjustments contribute to the adaptation of rice under salt stress. Branched-chain amino acids (BCAA) are three essential amino acids that cannot be synthesized by humans or animals. However, little is known about the role of BCAA in response to salt stress in plants.center dot Here, we showed that BCAAs may function as scavengers of reactive oxygen species (ROS) to provide protection against damage caused by salinity. We determined that branched-chain aminotransferase 2 (OsBCAT2), a protein responsible for the degradation of BCAA, positively regulates salt tolerance.center dot Salt significantly induces the expression of OsBCAT2 rather than BCAA synthesis genes, which indicated that salt mainly promotes BCAA degradation and not de novo synthesis. Metabolomics analysis revealed that vitamin B5 (VB5) biosynthesis pathway intermediates were higher in the OsBCAT2-overexpressing plants but lower in osbcat2 mutants under salt stress. The salt stress-sensitive phenotypes of the osbcat2 mutants are rescued by exogenous VB5, indicating that OsBCAT2 affects rice salt tolerance by regulating VB5 synthesis.center dot Our work provides new insights into the enzymes involved in BCAAs degradation and VB5 biosynthesis and sheds light on the molecular mechanism of BCAAs in response to salt stress.

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