Novel Drug Delivery Systems: An Important Direction for Drug Innovation Research and Development

文献类型： 外文期刊

第一作者： Chen, Qian

作者： Chen, Qian;Yang, Zhen;Liu, Haoyu;Man, Jingyuan;Oladejo, Ayodele Olaolu;Ibrahim, Sally;Wang, Shengyi;Hao, Baocheng;Oladejo, Ayodele Olaolu;Ibrahim, Sally

作者机构：

关键词： novel drug delivery system; targeting technology; carrier; nanotechnology; three-dimensional printing (3DP) technology

期刊名称：PHARMACEUTICS （ 影响因子：5.4； 五年影响因子：6.0 ）

ISSN：

年卷期： 2024 年 16 卷 5 期

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收录情况： SCI

摘要： The escalating demand for enhanced therapeutic efficacy and reduced adverse effects in the pharmaceutical domain has catalyzed a new frontier of innovation and research in the field of pharmacy: novel drug delivery systems. These systems are designed to address the limitations of conventional drug administration, such as abbreviated half-life, inadequate targeting, low solubility, and bioavailability. As the disciplines of pharmacy, materials science, and biomedicine continue to advance and converge, the development of efficient and safe drug delivery systems, including biopharmaceutical formulations, has garnered significant attention both domestically and internationally. This article presents an overview of the latest advancements in drug delivery systems, categorized into four primary areas: carrier-based and coupling-based targeted drug delivery systems, intelligent drug delivery systems, and drug delivery devices, based on their main objectives and methodologies. Additionally, it critically analyzes the technological bottlenecks, current research challenges, and future trends in the application of novel drug delivery systems.

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