Developmental effects and lipid disturbances of zebrafish embryos exposed to three newly recognized bisphenol A analogues

文献类型： 外文期刊

第一作者： Zhao, Xiaoyu

作者： Zhao, Xiaoyu;Liu, Zaiteng;Zhang, Yining;Pan, Yecan;Wang, Tiancai;Wang, Zishuang;Li, Zishu;Zeng, Qingxiao;Qian, Yongzhong;Qiu, Jing;Mu, Xiyan

作者机构：

关键词： Bisphenol A Analogues; Zebrafish embryos; Developmental effects; Lipid disturbances; Lipid metabolism disorder

期刊名称：ENVIRONMENT INTERNATIONAL （ 影响因子：10.3； 五年影响因子：11.1 ）

ISSN： 0160-4120

年卷期： 2024 年 189 卷

页码：

收录情况： SCI

摘要： Bisphenol G (BPG), bisphenol M (BPM) and bisphenol TMC (BPTMC), are newly recognized analogues of bisphenol A (BPA), which have been detected in multiple environmental media. However, the understanding of their negative impacts on environmental health is limited. In this study, zebrafish embryos were exposed to BPA and the three analogues (0.1, 10, and 1000 mu g/L) to identify their developmental toxic effects. According to our results, all of the three analogues induced significant developmental disorders on zebrafish embryos including inhibited yolk sac absorption, altered heart rate, and teratogenic effects. Oil Red O staining indicated lipid accumulation in the yolk sac region of zebrafish after bisphenol analogues exposure, which was consistent with the delayed yolk uptake. Untargeted lipidomic analysis indicated the abundance of triacylglycerols, ceramides and fatty acids was significantly altered by the three analogues. The combined analysis of lipidomics and transcriptomics results indicated BPG and BPM affected lipid metabolism by disrupting peroxisome proliferatoractivated receptor pathway and interfering with lipid homeostasis and transport. This partly explained the morphological changes of embryos after bisphenol exposure. In conclusion, our study reveals that BPG, BPM and BPTMC possess acute and developmental toxicity toward zebrafish, and the developmental abnormalities are associated with the disturbances in lipid metabolism.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序