A transcription factor ZmGLK36 confers broad resistance to maize rough dwarf disease in cereal crops

文献类型： 外文期刊

第一作者： Xu, Zhennan

作者： Xu, Zhennan;Zhou, Zhiqiang;Cheng, Zixiang;Wang, Feifei;Li, Mingshun;Li, Gongjian;Li, Wenxue;Du, Qingguo;Wang, Ke;Lu, Xin;Tai, Yuxin;Chen, Runyi;Hao, Zhuanfang;Han, Jienan;Yong, Hongjun;Zhang, Degui;Weng, Jianfeng;Li, Xinhai;Zhou, Yu;Wang, Zhenhua;Chen, Yanping;Meng, Qingchang;Kong, Xiaomin;Tie, Shuanggui;Mu, Chunhua;Song, Weibin;Wang, Haiyang

作者机构：

期刊名称：NATURE PLANTS （ 影响因子：18.0； 五年影响因子：18.6 ）

ISSN： 2055-026X

年卷期： 2023 年 9 卷 10 期

页码：

收录情况： SCI

摘要： Maize rough dwarf disease (MRDD), caused by maize rough dwarf virus (MRDV) or rice black-streaked dwarf virus (RBSDV), seriously threatens worldwide production of all major cereal crops, including maize, rice, wheat and barley. Here we report fine mapping and cloning of a previously reported major quantitative trait locus (QTL) (qMrdd2) for RBSDV resistance in maize. Subsequently, we show that qMrdd2 encodes a G2-like transcription factor named ZmGLK36 that promotes resistance to RBSDV by enhancing jasmonic acid (JA) biosynthesis and JA-mediated defence response. We identify a 26-bp indel located in the 5 & PRIME; UTR of ZmGLK36 that contributes to differential expression and resistance to RBSDV in maize inbred lines. Moreover, we show that ZmDBF2, an AP2/EREBP family transcription factor, directly binds to the 26-bp indel and represses ZmGLK36 expression. We further demonstrate that ZmGLK36 plays a conserved role in conferring resistance to RBSDV in rice and wheat using transgenic or marker-assisted breeding approaches. Our results provide insights into the molecular mechanisms of RBSDV resistance and effective strategies to breed RBSDV-resistant cereal crops.

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