Miniaturized electrochemical sensors and their point-of-care applications

文献类型： 外文期刊

第一作者： Zhang, Wei

作者： Zhang, Wei;Wang, Ruiguo;Wang, Peilong;Luo, Fang;Lin, Zhenyu

作者机构：

关键词： Miniaturized electrochemical sensors; Point-of-care testing; DNA-based miniaturized electrochemical sensor; Paper-based electrochemical sensor; Microfluidics-based electrochemical sensor; Miniaturized capillary electrophoresis-based sensor

期刊名称：CHINESE CHEMICAL LETTERS （ 影响因子：6.779； 五年影响因子：4.558 ）

ISSN： 1001-8417

年卷期： 2020 年 31 卷 3 期

页码：

收录情况： SCI

摘要： Most of the current analytical methods depend largely on laboratory-based analytical techniques that require expensive and bulky equipment, potentially incur costly testing, and involve lengthy detection processes. With increasing requirements for point-of-care testing (POCT), more attention has been paid to miniaturized analytical devices. Miniaturized electrochemical (MEC) sensors, including different material-based MEC sensors (such as DNA-, paper-, and screen electrode-based), have been in strong demand in analytical science due to their easy operation, portability, high sensitivity, as well as their short analysis time. They have been applied for the detection of trace amounts of target through measuring changes in electrochemical signal, such as current, voltage, potential, or impedance, due to the oxidation/reduction of chemical/biological molecules with the help of electrodes and electrochemical units. MEC sensors present great potential for the detection of targets including small organic molecules, metal ions, and biomolecules. In recent years, MEC sensors have been broadly applied to POCT in various fields, including health care, food safety, and environmental monitoring, owing to the excellent advantages of electrochemical (EC) technologies. This review summarized the state-of-the-art advancements on various types of MEC sensors and their applications in POCT. Furthermore, the future perspectives, opportunities, and challenges in this field are also discussed. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

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