Towards Innovative Design and Application of Recombinant Eimeria as a Vaccine Vector

文献类型： 外文期刊

第一作者： Tang, Xinming

作者： Tang, Xinming;Liu, Xianyong;Suo, Xun;Tang, Xinming;Liu, Xianyong;Suo, Xun;Tang, Xinming

作者机构：

关键词： vaccine vector; Eimeria; transient and stable transfection; immune responses; protection; immune response

期刊名称：INFECTION AND IMMUNITY （ 影响因子：3.441； 五年影响因子：3.702 ）

ISSN： 0019-9567

年卷期： 2020 年 88 卷 5 期

页码：

收录情况： SCI

摘要： Efficient delivery of antigenic cargo to trigger protective immune responses is critical to the success of vaccination. Genetically engineered microorganisms, including virus, bacteria, and protozoa, can be modified to carry and deliver heterologous antigens to the host immune system. The biological vectors can induce a broad range of immune responses and enhance heterologous antigen-specific immunological outcomes. The protozoan genus Eimeria is widespread in domestic animals, causing serious coccidiosis. Eimeria parasites with strong immunogenicity are potent coccidiosis vaccine candidates and offer a valuable model of live vaccines against infectious diseases in animals. Eimeria parasites can also function as a vaccine vector. Herein, we review recent advances in design and application of recombinant Eimeria as a vaccine vector, which has been a topic of ongoing research in our laboratory. By recapitulating the establishment of an Eimeria transfection platform and its application, it will help lay the foundation for the future development of effective parasite-based vaccine delivery vectors and beyond.

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