Beneficial effects of flaxseed polysaccharides on metabolic syndrome via gut microbiota in high-fat diet fed mice

文献类型： 外文期刊

第一作者： Yang, Chen

作者： Yang, Chen;Xu, Zhenxia;Deng, Qianchun;Huang, Qingde;Huang, Fenghong;Huang, Fenghong;Wang, Xu

作者机构：

关键词： Flaxseed polysaccharides; Metabolic syndrome; Gut microbiota; Akkermansia

期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：6.475； 五年影响因子：6.508 ）

ISSN： 0963-9969

年卷期： 2020 年 131 卷

页码：

收录情况： SCI

摘要： Flaxseed (Linum usitatissimum L.) is known as healthy food for its anti-obesity and lipid modulating properties. However, the effects of flaxseed polysaccharide (FSP) on metabolic syndrome (MetS) and gut microbiota are still poorly understood. Here, we investigated the effects of FSP on lipid metabolism and gut microbiota in high-fat-diet-fed mice. FSP effectively reduced the serum fasting glucose, total triglyceride and total cholesterol levels. FSP consumption adipose accumulation impacted the gut microbiome at different taxonomic levels by increasing the proportions of beneficial Akkermansia and Bifidobacterium and decreasing the disease or obesity associated Oscillospira and Odoribacteraceae. These changes were highly correlated with the regulation of expression levels of lipid metabolism involved genes in the liver. The restoration of total SCFAs, especially propionate and butyrate might be an important strategy for mitigating HFD induced metabolic disorders. These findings suggest that FSP may use as a prebiotic for preventing MetS by modulating the gut microbiota.

分类号：

  • 相关文献

[1]Beneficial effects of flaxseed polysaccharides on metabolic syndrome via gut microbiota in high-fat diet fed mice. Yang, Chen,Xu, Zhenxia,Deng, Qianchun,Huang, Qingde,Huang, Fenghong,Huang, Fenghong,Wang, Xu. 2020

作者其他论文 更多>>

微信小程序