文献类型： 外文期刊
第一作者： Chen, Wei
作者： Chen, Wei;Yang, Qing;Chen, Wei;Yang, Qing;Yang, Qing
作者机构：
关键词： insect chitinase; physiological role; molting; structure; inhibitor; pesticide
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）
ISSN： 0021-8561
年卷期： 2020 年 68 卷 16 期
页码：
收录情况： SCI
摘要： Chitinase (EC 3.2.1.14) is an enzyme to breakdown beta-1,4-glycosidic bonds in chitin and chitooligosaccharides. The loss of chitinase enzymatic activity in insects results in severe exoskeleton defects and lethality at all developmental stages, indicating that insect chitinases can be promising pesticide targets. However, there are no pesticides known to target chitinases. This perspective will focus on the latest research progress of insect chitinases, paying special attention to crystal structures and chemical biology advances in the field. The physiological importance and unique structural features of insect chitinases may ensure the development of new pesticides through a novel acting mode.
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