Antivirulence properties and related mechanisms of spice essential oils: A comprehensive review

文献类型： 外文期刊

第一作者： Zhang Dan

作者： Zhang Dan;Gan Ren-You;Zhang, Jia-Rong;Farha, Arakkaveettil Kabeer;Corke, Harold;Gan Ren-You;Li Hua-Bin;Zhu Fan;Wang Xiao-Hong

作者机构：

关键词： biofilm; mechanisms; motility; quorum sensing; spice essential oils; toxin

期刊名称：COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY （ 影响因子：12.811； 五年影响因子：15.365 ）

ISSN： 1541-4337

年卷期： 2020 年 19 卷 3 期

页码：

收录情况： SCI

摘要： In recent decades, reduced antimicrobial effectiveness, increased bacterial infection, and newly emerged microbial resistance have become global public issues, leading to an urgent need to find effective strategies to counteract these problems. Strategies targeting bacterial virulence factors rather than bacterial survival have attracted increasing interest, since the modulation of virulence factors may prevent the development of drug resistance in bacteria. Spices are promising natural sources of antivirulence compounds owing to their wide availability, diverse antivirulence phytochemical constituents, and generally favorable safety profiles. Essential oils are the predominant and most important antivirulence components of spices. This review addresses the recent efforts of using spice essential oils to inhibit main bacterial virulence traits, including the quorum sensing system, biofilm formation, motility, and toxin production, with an intensive discussion of related mechanisms. We hope that this review can provide a better understanding of the antivirulence properties of spice essential oils, which have the potential to be used as antibiotic alternatives by targeting bacterial virulence.

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