文献类型： 外文期刊

第一作者： Cao Guiling

作者： Cao Guiling;Jiang Yunliang;Cao Guiling;Gao Zeyang;Chu Mingxing;Chu Mingxing

作者机构：

关键词： expression pattern; gene mutation; glucose metabolism; Lin28a; Lin28b; onset of puberty

期刊名称：MOLECULAR REPRODUCTION AND DEVELOPMENT （ 影响因子：2.609； 五年影响因子：3.47 ）

ISSN： 1040-452X

年卷期： 2020 年 87 卷 5 期

页码：

收录情况： SCI

摘要： Lin28a and Lin28b, homologs of the Caenorhabditis elegans Lin28 gene, play important roles in cell pluripotency, reprogramming, and tumorigenicity. Recently, genome-wide association and transgenic studies showed that Lin28a and/or Lin28b gene were involved in the onset of mammalian puberty, the stage representing the attainment of reproduction capacity; however, the detailed mechanism of these genes in mammalian puberty remains largely unknown. The present paper reviews the research progress on the roles of Lin28a/b genes in the onset of mammalian puberty by analyzing the results coming from gene expression patterns, mutations, and transgenic studies, and put forward possible pathways for further studies on their roles in animal reproduction.

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