High-Protein Diet Induces Hyperuricemia in a New Animal Model for Studying Human Gout

文献类型： 外文期刊

第一作者： Hong, Fan

作者： Hong, Fan;Xu, Pengfei;Wang, Jialin;Xue, Tingting;Dai, Shu;Pan, Shijia;Guo, Yuan;Li, Letong;Qiao, Xiaoxiao;Zhai, Yonggong;Hong, Fan;Pan, Shijia;Guo, Yuan;Li, Letong;Qiao, Xiaoxiao;Zhai, Yonggong;Zheng, Aijuan;Liu, Guohua;Zheng, Aijuan;Liu, Guohua;Xu, Pengfei;Xu, Pengfei;Xie, Xinlu

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关键词： hyperuricemia; high protein diet; gout; chicken; renal disease

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）

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年卷期： 2020 年 21 卷 6 期

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收录情况： SCI

摘要： Hyperuricemia is a central risk factor for gout and increases the risk for other chronic diseases, including cardiometabolic disease, kidney disease, and hypertension. Overproduction of urate is one of the main reasons for hyperuricemia, and dietary factors including seafoods, meats, and drinking are contributed to the development of it. However, the lack of a suitable animal model for urate metabolism is one of the main reasons for the delay and limitations of hyperuricemia research. Combining evolutionary biological studies and clinical studies, we conclude that chicken is a preferred animal model for hyperuricemia. Thus, we provided chickens a high-protein diet (HPD) to evaluate the changes in the serum urate levels in chickens. In our study, the HPD increased the serum urate level and maintained it at a long-term high level in chickens. Long-term high serum urate levels induced an abnormal chicken claw morphology and the precipitation of monosodium urate (MSU) in joint synovial fluid. In addition, a long-term HPD also decreased the glomerular filtration rate and induced mild renal injury. Most importantly, allopurinol and probenecid displayed the positive effects in decreasing serum urate and then attenuated hyperuricemia in chicken model. These findings provide a novel model for hyperuricemia and a new opportunity to further investigate the effects of long-term hyperuricemia on other metabolic diseases.

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