Vesicular stomatitis virus glycoprotein suppresses nuclear factor kappa-B- and mitogen-activated protein kinase-mediated pro-inflammatory responses dependent on sialic acids

文献类型： 外文期刊

第一作者： Li, Rui

作者： Li, Rui;Qiao, Songlin;Chen, Xin-xin;Xing, Guangxu;Li, Xuewu;Zhang, Gaiping;Zhang, Gaiping;Zhang, Gaiping

作者机构：

关键词： VSV; Glycoprotein; Pro-inflammatory responses; NF-kappa B; MAPK; Sialic acids

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

ISSN： 0141-8130

年卷期： 2020 年 152 卷

页码：

收录情况： SCI

摘要： Vesicular stomatitis (VS), characterized by vesicular lesions, produces significant economic losses in livestock industry. Infection by its causative agent, VS virus (VSV), has been previously shown to be mediated by the glyco-protein (G) during attachment, endocytosis and membrane fusion. In the current study, we revealed a novel role of VSV G protein in negative regulation of host cell pro-inflammatory responses. We determined that VSV G protein inhibited lipopolysaccharide (LPS)-induced pro-inflammatory responses as naive VSV virions in murine peritoneal macrophage-like cell line RAW 264.7. Furthermore, we identified that VSV G protein suppressed nuclear factor kappa-B (NF-kappa B) and mitogen-activated protein kinase (MAPK)-mediated pro-inflammatory path-ways in a dose-dependent manner. Moreover, we demonstrated that alpha 2-3-linked sialic acids on VSV G protein were involved in antagonizing NF-kappa B- and MAPK-mediated pro-inflammatory responses. All these results expand the knowledge of VSV pathogenesis and strengthen the importance of VSV G protein in host innate immunity, which support implications for the development of VSV-based vaccination and oncolysis. (C) 2020 Elsevier B.V. All rights reserved.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序