Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis

文献类型： 外文期刊

第一作者： Xiao, Qi

作者： Xiao, Qi;Tang, Jianna;Wang, Xiaoshuang;Xue, Xiaomin;Li, Mengxue;Wang, Minjing;Zhao, Yinan;Liu, Jingze;Wang, Hui;Hu, Yuhong;Yang, Xiaohong;Yang, Xiaohong

作者机构：

关键词： Tick; salivary gland; apoptosis; data-independent acquisition; RNA interference; Hippo

期刊名称：KOREAN JOURNAL OF PARASITOLOGY （ 影响因子：1.341； 五年影响因子：1.669 ）

ISSN： 0023-4001

年卷期： 2020 年 58 卷 2 期

页码：

收录情况： SCI

摘要： The ticks feed large amount of blood from their hosts and transmit pathogens to the victims. The salivary gland plays an important role in the blood feeding. When the female ticks are near engorgement, the salivary gland gradually loses its functions and begins to rapidly degenerate. In this study, data-independent acquisition quantitative proteomics was used to study changes in the phosphorylation modification of proteins during salivary gland degeneration in Haemaphysalis longicomis. In this quantitative study, 400 phosphorylated proteins and 850 phosphorylation modification sites were identified. Trough RNA interference experiments, we found that among the proteins with changes in phosphorylation, apoptosis-promoting Hippo protein played a role in salivary gland degeneration.

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