"Development and application of analytical detection techniques for droplet -based micro fluidics"-A review

文献类型： 外文期刊

第一作者： Liu, Wen-wen

作者： Liu, Wen-wen;Zhu, Ying

作者机构：

关键词： Droplet; Microfluidics; Analytical detection method; Optical detection; Electrical detection; Mass spectrometry; Nuclear magnetic resonance spectroscopy

期刊名称：ANALYTICA CHIMICA ACTA （ 影响因子：6.558； 五年影响因子：6.228 ）

ISSN： 0003-2670

年卷期： 2020 年 1113 卷

页码：

收录情况： SCI

摘要： Droplet-based microfluidics has emerged as a powerful platform for high-throughput and low-volume analysis and screening. At present, droplet-based microfluidics is transitioning from the proof-of-concept stage to real-world applications. During this process, analytical detection techniques play indispensable roles for successfully implementing droplet-based chemical or biological assays. In this review, we provide an overview of recent developments in analytical techniques for droplet analysis and elucidate the advantages and limitations of each technique. We cover the majority of technology categories, including optical detection, electrical detection, mass spectrometry, and nuclear magnetic resonance spectroscopy. Additionally, we highlight new research areas that have been enabled by these technical advances. Finally, we provide perspectives on both future technological directions and potential enabling applications. (C) 2020 Elsevier B.V. All rights reserved.

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