Myo-inositol enhances the low-salinity tolerance of turbot (Scophthalmus maximus) by modulating cortisol synthesis

文献类型： 外文期刊

第一作者： Cui, Wenxiao

作者： Cui, Wenxiao;Cui, Wenxiao;Ma, Aijun;Wang, Xinan;Huang, Zhihui;Cui, Wenxiao;Ma, Aijun;Wang, Xinan;Huang, Zhihui

作者机构：

关键词： Turbot; myo-inositol; Low salinity; Cortisol; Osmoregulation

期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：3.575； 五年影响因子：3.381 ）

ISSN： 0006-291X

年卷期： 2020 年 526 卷 4 期

页码：

收录情况： SCI

摘要： Myo-inositol is a major intracellular osmolyte that can be accumulated to protect cells from a variety of stresses, including fluctuations in the osmolality of the environment, and cortisol is thought to be an osmotic hormone in teleost fish. In this study, dietary myo-inositol resulted in increased Na+-K+-ATPase activity and gene expression of partial ion channel genes and prolonged survival time of turbot (Scophthalmus maximus) under low salinity. The cortisol regulated by dietary myo-inositol also was correlated with these outcomes. The optimal concentrations of cortisol stimulated gill Na+-K+-ATPase activity and increased the expression of ion channel genes to enhance low salinity tolerance, as indicated by longer survival time under low salinity. When cortisol level was suppressed, myo-inositol failed to increase the survival time of turbot under low salinity, and strong correlations between cortisol concentration and Na+-K+-ATPase activity, expression of partial ion channel genes, and survival time of turbot were detected. These results showed that myo-inositol enhanced the low salinity tolerance of turbot by modulating cortisol synthesis. (C) 2020 Elsevier Inc. All rights reserved.

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