Synthesis, Crystal Structure and Inhibitory Activities of 2-(N-Tert-Butoxycarbonylamino)Pyridine Derivatives

文献类型： 外文期刊

第一作者： Shi, Yun-Lian

作者： Shi, Yun-Lian;Shi, Xu-Gen;Nie, Xu-Liang;Huang, Tao;Shi, Ming-Zhu;Peng, Da-Yong;Ren, Xue-Xiang;Zhao, Ming-Yu;Li, Bao-Tong

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关键词： 2-(N-tert-butoxycarbonylamino) pyridine derivatives; Synthesis; Crystal structure; Inhibitory activities

期刊名称：JOURNAL OF CHEMICAL CRYSTALLOGRAPHY （ 影响因子：0.603； 五年影响因子：0.51 ）

ISSN： 1074-1542

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收录情况： SCI

摘要： 2-(N-tert-butoxycarbonylamino) pyridine and 2-(N-tert-butoxycarbonylamino)-3-methylpyridine were synthesized in a one-step method using either 2-aminopyridine or 2-amino-3-methyphyridine with tert-butylcarbonyl anhydride as the starting materials. The products were characterized by single-crystal X-ray diffraction, H-1 NMR, C-13 NMR, and HRMS. The biological activity of the two compounds against five fungi was determined. 2-(N-tert-butoxycarbonylamino) pyridine has more than 50% inhibitory activity against Pyricularia oryzae, Colletotrichum gloeosporioides, and Alternaria alternate. In addition, the inhibitory activity of 2-(N-tert-butoxycarbonylamino)-3-methylpyridine against Alternaria alternate reached 67.69%. Graphic Two 2-BOC aminopyridine derivatives were synthesized and structurally characterized by H-1 NMR, C-13 NMR, HRMS analysis and X-ray crystal diffraction. The inhibitory activity both compounds was studied. [GRAPHICS] .

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